By train.
From Rome: Roma Tiburtina Station - Pescara Centrale
Duration: 3 hours and a half roughly
From Milano: Milano Central Station - Pescara Centrale
Duration: 6 hours roughly
More info: Trenitalia.it

By car.
From Roma to Pescara: Autostrada (highway) A25/E80.
Duration: 5 hours and a half roughly .
From Milano to Pescara: Autostrada (highway) A14.
Duration: 5 hours and a half roughly
More info: ViaMichelin.it

By coach.
From Rome to Pescara:
P.le Staz. Tiburtina - Pescara P.le Repubblica
More info: Prontobus.com - Arpaonline.it

Aereo
Da Roma a Pescara:
Fiumicino - Aeroporto Int. d' Abruzzo
Durata: 50 minuti circa
Da Milano a Pescara:
Linate / Malpensa - Aeroporto Int. d' Abruzzo
Durata: 1 ora e 5 minuti circa.
Per saperne di più: Aeroporti Milano - Aeroporti Roma